I have been using Medicfusion for a little over a year and I am really happy with it. I was using Soape for two years before that and have used CT while backing up another doc. I really like the fact that it is web based and I do not have to worry about backups, upgrades, or hardware issues. It is very easy to use and it does a great job of helping to managed patient flow and notes.
It has a SALT feature which can come in handy.
The exam listings get a little crowded and hard to work with sometimes but I believe that can be customized for an additional charge if I get annoyed.
The patient portal works really well although I don't use it to it's full potential. It sends out reminders with no interaction other than the initial setup - very cool.
The macros are easy to write and use so that helps with charting as well.
I recommend taking a look at what they have to offer.